Search on: CYR61 CTGF NOV MATRICELLULAR PROTEINS 
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Descriptor English:   CCN Intercellular Signaling Proteins 
Descriptor Spanish:   Proteínas CCN de Señalización Intercelular 
Descriptor Portuguese:   Proteínas de Sinalização Intercelular CCN 
Synonyms English:   CCN Family Proteins
CYR61 CTGF NOV Matricellular Proteins
Matricellular CCN Proteins  
Tree Number:   D12.644.276.200
D12.776.467.200
D12.776.860.300.200
D23.529.237
Definition English:   A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN. 
History Note English:   2009 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   53123 
Unique Identifier:   D055511 

Occurrence in VHL:
 

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